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Tan Xiaojun
·Senior reproductive medicine expert
·Postdoctoral fellow at Peking University
·PhD candidate at Xiangya School of Medicine, Central South University
·Master’s tutor at Central South University
· Master's degree candidate in reproductive medicine at the University of South China
· Professional training at Huazhong University of Science and Technology and Tongji Hospital Reproductive Center
Expertise:
diagnosis and treatment of infertility, first/second/third generation IVF (including
          egg/sperm donation), microsperm retrieval, embryo freezing and resuscitation, artificial
          insemination (including husband's sperm and sperm donation), paternity testing, chromosomal
          disease
          diagnosis, high-throughput gene sequencing, endometrial receptivity gene testing and other
          clinical
          technology applications. Many of these technologies are at the leading level both domestically
          and
          internationally.
Tags:
Embryo Transfer, Kyrgyzstan Tulip International Reproductive Center, Overseas IVF, Single Birth Assistance Institution, Cross border Assisted Reproduction, Kyrgyzstan Assisted Reproduction, Third Generation IVF, Overseas IVF, Lightning Protection, Single Surrogacy, Gay Surrogacy, Male Infertility, Multiple Cyst Ovary, POS Ovulation, Elderly Pregnancy, Chromosomal Abnormalities, Genetic Abnormalities, Child Genetic Diseases, Fertility Preservation, Transgender Fertility, Sperm Freezing Technology, Hormone Replacement Therapy, Female Homosexuality, Male Homosexuality, Same Partner LES GAY, Elderly Maternal Azoospermia, Ovulation Promotion
Date:
2025.11.14
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Is there still hope for becoming a father with a sperm abnormality rate of 99%?

When a semen analysis report is presented with the words' Normal Form Sperm Rate: 1% ', many men and their partners instantly fall into great anxiety and confusion.


99% of sperm are deformed, is it impossible for me to have my own child


At Tulip International Reproductive Center, we would like to tell you not to be intimidated by this number for now. With the help of modern assisted reproductive technology, the door of hope remains open.


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Q1: Does the high sperm abnormality rate of 99% mean that there are no available healthy sperm at all?

A: Absolutely not. This is a very common misconception. The sperm abnormality rate is 99%, which refers to 99 out of every 100 sperm that do not meet the strictest "perfect" standard in sampling inspection.


We first need to understand two key points:


The absolute value of quantity: A normal ejaculation can result in a total sperm count of tens of millions or even billions. Even if only 1% of them are in normal form, it means that there are still hundreds of thousands or even millions of "elite" sperm present in absolute numbers. This may be difficult for natural pregnancy, but for in vitro fertilization technology, it is more than enough.


Precise screening of technology: The core of the second-generation in vitro fertilization (ICSI) technology is that experienced embryologists manually select the best shaped and most energetic sperm from a multitude of troops under a high-powered microscope, and inject it directly into the egg to complete fertilization.


Therefore, a 99% deformity rate is not a judgment, but a clear signal that you need more advanced assisted reproductive technology to help you choose the best.


Q2: Why has the World Health Organization (WHO) standard for normal sperm morphology decreased from ≥ 15% to ≥ 4% now? Is it standard water release?

A: On the contrary, this is because the evaluation criteria have become stricter and more scientific.


Old standard (4th edition, 1999): At that time, the evaluation criteria for sperm morphology were relatively loose.


New Standard (Fifth Edition, 2010 present): Adopting the strict standard known as "Kruger", there are extremely precise size and shape requirements for every detail of the sperm head, neck, and tail, and any minor flaw will be judged as "deformity".


Behind the standard update is a large amount of clinical data support: studies have found that after using strict standards for evaluation, men with a normal morphology rate of less than 4% have a significantly reduced probability of natural pregnancy, but it does not mean that they are completely unable to conceive. This 4% threshold can more accurately predict the probability of natural conception and provide a more reliable basis for doctors to determine whether to intervene in assisted reproductive technology.


Q3: How do embryologists determine whether a sperm is "normal" or "abnormal" in the laboratory?

A: Embryologists are like the "chief interviewers" of sperm. They will magnify the semen sample under a high-powered microscope at 400 times or even higher, and carefully observe each 'candidate':


A normal sperm should look like this:


Head: Smooth oval shape, moderate size.


Neck: Clear and securely connected.


Tail: Single, straight, without curling or breakage.


Common "deformed" players may include:


Head deformities: large head, small head, double head, pear shaped head, etc.


Neck deformity: The neck is thick or has folds.


Tail deformities: twin tails, curled tails, no tails, etc.


In ICSI operation, the task of embryologists is to find the "chosen one" with the closest form to perfection among thousands of such "crooked melon cracked dates".


Q4: Can you share a real case of the Tulip International Reproductive Center to give us some confidence?

A: Of course you can. Mr. Zhao, who is 38 years old, and his wife have been preparing for pregnancy for many years, during which they experienced a failed artificial insemination (IUI). Mr. Zhao's semen analysis report has greatly impacted him: the normal sperm rate is only 0.5%, and the forward motility is only 15%. The previous doctors were very pessimistic about the prospects of their natural pregnancy.


Arriving at Tulip: They came to Tulip International Reproductive Center with thick medical records and heavy hearts. After a detailed evaluation, our experts clearly informed them that this situation is an absolute indication for ICSI technology and has a high chance of success.


Precision treatment: We have developed an efficient ovulation induction plan for Mrs. Zhao, and our laboratory team has made full preparations for Mr. Zhao's valuable sperm. On the day of egg retrieval, our chief embryologist spent a long time under the microscope matching each of the 10 mature eggs retrieved with the best morphology and vitality of the 10 sperm.


Ideal result: Ultimately, 8 eggs were successfully fertilized and 4 high-quality blastocysts were cultivated. After the first transplant, Mrs. Zhao successfully became pregnant and now they have a healthy baby.


Mr. Zhao's case strongly proves that the numbers on the semen report are only the starting point, and top laboratory technology and experienced embryologists are the key to success or failure.


Q5: For men with a high rate of sperm abnormalities, how should they choose between first generation IVF and second-generation ICSI?

A: This is a crucial choice that directly affects the success rate.


The first generation of in vitro fertilization (IVF) involves placing processed sperm and eggs in the same culture dish, allowing them to "freely fall in love" and undergo natural selection for fertilization. This method is suitable for couples with generally normal sperm quality. For sperm with high deformity rates, they are at an absolute disadvantage in competition and find it difficult to successfully penetrate the egg, resulting in a high failure rate of fertilization.


Second generation IVF (ICSI): The full name is "intracytoplasmic sperm injection". It bypasses the process of natural selection and is arranged by embryologists directly, delivering the highest quality single sperm directly into the egg through microinjection needles. This is a technology specifically designed to address male factor infertility, including severe oligozoospermia, asthenozoospermia, and teratozoospermia.


If your sperm normal morphology rate is below the reference standard of 4%, especially as low as 1% or even lower as in the case, we strongly recommend that you directly choose ICSI technology, which is the most effective way to maximize the utilization of every valuable egg, improve fertilization rate and final success rate.




A sperm abnormality rate of 99% does not necessarily mean that there is only 1% left in fertility hope. At Tulip International Reproductive Center, we believe in the power of science. Through precise diagnosis, personalized solutions, and powerful embryo laboratory technology, we are confident in helping you find possibilities from the impossible. Please do not be knocked down by a single report, let us be your partners fighting side by side, welcoming the arrival of new life together.


For fertility consultation in Kyrgyzstan, please contact your dedicated consultant

/Fertility Consultation /

Dr.Chan


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