Third-generation IVF

Doctor, if we want to do it, we'll do the best and go straight to the third generation of IVF

In our clinic, we often feel the anticipation and determination of expectant parents.

In the general perception, the name "Third Generation" seems to carry a halo - it sounds more advanced, technologically advanced, and like an express train to successful pregnancy.

We fully understand the feeling of sacrificing everything for the next generation. However, as rigorous guardians of life sciences, we have a responsibility to tell you that the value of third-generation IVF (PGT, pre implantation genetic testing) does not lie in being "more expensive" or "more advanced", but in the "precision" and "necessity" it provides.

It is like an experienced 'life engineer', helping us identify and avoid potential genetic 'reefs' at the source of our incubation journey.

In fact, "test tube baby first generation, second generation, and third generation" is just a common term for the three types of test tube babies.

Their corresponding scientific names are: "IVF Generation 1" - in vitro fertilization embryo transfer, "IVF Generation 2" - intracytoplasmic sperm injection technology, "IVF Generation 3" - pre implantation genetic diagnosis/screening.

First generation IVF: suitable for female infertility caused by various factors such as fallopian tube diseases, ovulation disorders, endometriosis, male oligozoospermia, unexplained infertility, immunological infertility, etc.

Second generation IVF: suitable for severe oligozoospermia, asthenozoospermia, teratozoospermia, irreversible obstructive azoospermia, spermatogenic dysfunction (excluding genetic defects), in vitro fertilization failure, immune infertility, sperm acrosome abnormalities, and requiring pre implantation embryo genetic testing.

Third generation IVF: suitable for high-risk populations with single gene related genetic diseases, chromosomal diseases, adverse pregnancy and childbirth history, as well as those who may have abnormal offspring.

Third generation test tube (PGT) is not a single technology, but a combination of precise testing based on different genetic targets.

【 Core objective】: To safeguard the integrity of chromosome structure.

【 Applicable Family 】: One or both spouses are carriers of chromosomal structural abnormalities (such as balanced translocation, Roche translocation, inversion, etc.).

These expectant parents are usually very healthy themselves, but the chromosomes they pass on to the next generation are prone to errors, leading to the loss or duplication of embryonic chromosome fragments. This is an important cause of recurrent miscarriage and reproductive genetic syndrome in children.

We adopt the internationally mainstream NGS (next-generation sequencing) high-throughput sequencing technology, which is like scanning every "blueprint of life" with ultra-high resolution.

It can not only accurately identify whether the chromosome structure is complete, but also distinguish between "completely normal" embryos and "balanced carrier" embryos like their parents through advanced methods such as linkage analysis.

This is not only a screening, but also a hope to block the intergenerational transmission of genetic risk. At Tulip, we are committed to helping these families not only conceive a healthy baby, but also have the opportunity to completely bid farewell to this family inherited 'little regret' for the next generation, paving a truly secure path of inheritance.

【 Core objective 】 Ensure that embryos have the correct number of chromosomes (i.e. non diploid screening).

【 Suitable for Families 】

Elderly women (usually recommended to be over 35 years old)

Couples who have experienced unexplained recurrent spontaneous abortions

Couples who have experienced multiple failed IVF transplants

Scientific research has shown that abnormal chromosome numbers in embryos (one more or one less, i.e. aneuploidy) are the main "culprits" leading to embryonic arrest and transplant failure, and their incidence significantly increases with female age.

By biopsy of the trophoblast cells of the blastocyst, we used NGS technology to perform a "carpet style" count of all 23 pairs of chromosomes, ensuring that each transplanted "book of life" has no more, no less, and exactly complete chapters.

For families who have repeatedly suffered setbacks in their pursuit of a child, PGT-A can effectively improve the success rate of a single transplant, reduce the risk of miscarriage, and avoid unnecessary transplant waiting and physical and mental suffering.

【 Core objective 】 Diagnose and screen genetic diseases caused by single gene mutations.

【 Suitable for Families 】

Both or one spouse carries a known single gene genetic disease causing gene (such as thalassemia, hemophilia, spinal muscular atrophy (SMA), phenylketonuria (PKU), genetic hearing loss, etc.).

These diseases are like a family shadow, passed down from generation to generation, bringing endless pain and burden.

Before undergoing the IVF process, our genetics experts will conduct preliminary probe design and validation for your family. This highly personalized step is used to identify embryos carrying incorrect gene fragments during the embryonic stage.

The significance of PGT-M is revolutionary. It has transformed eugenics from a beautiful vision to a tangible reality.

Its core is that "diagnosis" precedes "transplantation".

It is not magic that can turn bad embryos into good ones, but it is a pair of technological "eyes" that can help us make the wisest and most responsible choices in the early stages of life.

This choice not only carries the peace of mind to avoid risks, but also represents the commitment of Tulip International Assisted Reproductive Hospital to every family - to use the most exquisite technology and warm care to safeguard the purity and health of the source of life.

Choosing third-generation test tubes is not due to blind pursuit of "high-end", but stems from a profound understanding of health and a deep responsibility for the future of the family.

If you or your family members are troubled by genetic issues or struggling on the road to having a child, please do not bear this pressure alone. At Tulip, our professional medical team and genetic counselors are here.