In medicine, women over 35 years old are generally defined as older mothers. As age increases, the decline in ovarian reserve function (decreased AMH) and the decline in egg quality (increased rate of chromosomal aneuploidy) are irreversible physiological phenomena. For women around 40 years old, the miscarriage rate and fetal malformation rate of natural conception significantly increase. Therefore, the third-generation in vitro fertilization technology (PGT, preimplantation genetic testing) has become an important means for older women to achieve eugenics and optimal childbirth.

However, technology is not omnipotent. How to maximize the clinical pregnancy rate of IVF with limited ovarian function? This requires a systematic scientific strategy.

1. "Egg-nurturing" strategy before entering the week

The core challenge of older women trying to conceive lies in the decline of mitochondrial function, leading to insufficient energy during egg fertilization and division. It is recommended to undergo targeted conditioning at least three months before entering the ovulation induction cycle. Supplementation with coenzyme Q10 can improve mitochondrial function, while DHEA (dehydroepiandrosterone) helps to enhance the ovarian microenvironment. Additionally, maintaining a regular sleep-wake cycle and an antioxidant diet can reduce oxidative stress in the body, laying the foundation for obtaining high-quality eggs.

2. Personalized ovulation induction protocol

Elderly women are not suitable for strong stimulation protocols like "flooding". The medical team at Tulip International Fertility Center usually develops a mild or minimal stimulation protocol based on the patient's basal FSH value and antral follicle count. Our goal is not to pursue the number of eggs retrieved, but rather the maturity and quality of the eggs, striving to obtain high-quality embryos that can be cultured and tested.

3. Precise application of third-generation in vitro fertilization technology (PGT)

For older women, abnormal embryo chromosomes are the primary cause of recurrent implantation failure and biochemical pregnancy. By utilizing PGT-A technology to screen the 23 pairs of chromosomes in blastocysts, abnormal embryos can be eliminated, and only embryos with normal chromosomes are transferred. This approach can significantly enhance the implantation rate of a single transfer and reduce the risk of miscarriage.

Mr. Chen Yibing, the founder of Tulip International Fertility Center, provided professional advice based on his years of clinical experience:

"In the clinical practice of Tulip Fertility Hospital, we have found that 'time' is the greatest enemy of older women, but 'strategy' is their best friend. For older patients with extremely low ovarian reserve, we do not recommend blind transfer. Instead, we adopt the 'accumulate embryos' strategy, which involves multiple minimal stimulation egg retrieval, centralizing the obtained embryos for blastocyst culture, and then performing PGT screening. Even if multiple attempts only yield one healthy blastocyst that passes the screening, its transfer success rate is much higher than blindly transferring multiple early embryos without testing. This is the principle we often refer to as 'fewer but better'. In addition, if treatment is conducted in Kyrgyzstan, the medical environment here allows us to seamlessly connect with legal fertility assistance programs after multiple unsuccessful attempts with autologous eggs, which is a powerful guarantee for the reproductive rights of older families."

In summary, for older women undergoing IVF with three generations, a three-pronged approach of "conditioning, protocol, and technology" is required. It is recommended to visit a reputable institution such as Tulip International Fertility Center as soon as possible for a comprehensive evaluation and to develop a scientific fertility assistance plan.

For fertility consultation in Kyrgyzstan, please contact your dedicated consultant

/Fertility Consultation /

Dr.Chan

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