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Tan Xiaojun
·Senior reproductive medicine expert
·Postdoctoral fellow at Peking University
·PhD candidate at Xiangya School of Medicine, Central South
University
·Master’s tutor at Central South University
· Master's degree candidate in reproductive
medicine at the University of South China
· Professional training at Huazhong University
of Science and Technology and Tongji
Hospital Reproductive Center
Expertise:
diagnosis and treatment of infertility, first/second/third generation IVF (including
egg/sperm donation), microsperm retrieval, embryo freezing and resuscitation, artificial
insemination (including husband's sperm and sperm donation), paternity testing, chromosomal
disease
diagnosis, high-throughput gene sequencing, endometrial receptivity gene testing and other
clinical
technology applications. Many of these technologies are at the leading level both domestically
and
internationally.
Is it necessary to do the third generation test tube overseas by balanced translocation? Overseas third generation test tube, PGT-SR, balanced translocation test tube process, repeated abortion, chromosome translocation, embryo screening, genetic counseling.
Is it necessary to make three generations of test tubes overseas by balanced translocation? Six judgment points to help you think clearly about whether to go abroad.
1. What is balanced translocation? Why does it affect fertility?
In genetics, * * Balanced Translocation)** refers to fragment exchange between two chromosomes, but the overall genetic material does not increase or decrease, so carriers usually have no obvious symptoms.
But the problem is:
In the process of reproduction, gametes (sperm or eggs) produced by this group of people may have unbalanced chromosome combinations.
Clinical observation shows that:
When pregnant naturally, the probability of abnormal embryos increases obviously.
It is prone to repeated abortion and fetal arrest.
Birth defects may occur in some cases.
According to the Study on Human Chromosome Abnormality and Reproductive Outcome (Source: International Journal of Reproductive Medicine Review Data), balanced translocation carriers:
The proportion of normal embryos fluctuates between 20% and 30%.
Abnormal or undeveloped embryos account for a higher proportion.
This is why some people will be advised to consider the third generation test tube (PGT-SR) technology.
How to solve the problem of balanced translocation in the second and third generation test tubes (PGT-SR)
The core of the third generation test tube is not to "improve the success rate", but:
Screening embryos with normal or developable chromosome structure.
Among them, the detection types for balanced translocation are:
PGT-SR（Preimplantation Genetic Testing for Structural Rearrangements）
Its basic principle:
In vitro fertilization to form embryos
Embryo development to blastocyst stage
A few cells were taken for chromosome structure analysis.
Select relatively normal embryos for transplantation.
At present, common detection technologies include:
NGS (next generation sequencing)
ACGH (comparative genomic hybridization)
Medical research shows that (source: ESHRE European Society of Human Reproduction and Embryology Guide):
PGT-SR can significantly reduce the risk of abortion.
Improve the effectiveness of a single transplant (but not the absolute result)
Expert tip: PGT-SR technology is mainly used to screen chromosomal structural abnormalities, which cannot cover all genetic problems and avoid all pregnancy risks, and needs to be evaluated in combination with individual conditions.
3. Who will consider going overseas to do three generations of test tubes?
Whether it is necessary to "go abroad" is not a technical issue in essence, but a comprehensive decision of policies, resources and individual needs.
People who usually consider overseas routes include:
People who have had multiple abortions or failed repeatedly
Confirmed balanced translocation of chromosomes
Multiple transplants failed.
People who need more flexible screening strategies
Some areas have certain restrictions on the scope of detection.
Individual countries are more open in technology application.
Older pregnant people (≥35 years old)
The abnormal rate of embryo increases with age.
The risk of overlapping with chromosome problems is higher
People who want to shorten the cycle or improve the alternatives.
The process of medical system varies greatly in different regions.
But it needs to be emphasized that:
Not all balanced translocation people need to go abroad.
Fourth, the core differences between overseas third-generation test tubes and local solutions
From the first principle, the essential difference lies in:
Institutional differences, not medical differences.
Can be disassembled into three points:
Technical level
PGT-SR technology is universal.
Different laboratories have different detection accuracy, but they are in the same system as a whole.
Policy level
In some areas, the screening scope and indications are stricter.
Some overseas countries have more flexible processes.
Process efficiency
The periodic arrangement of some overseas institutions is more centralized.
Some hospitals in China queue for a long time.
Expert tip: Technology itself is not the decisive difference, but laboratory quality and individual scheme design are the key variables.
Five, the basic process of overseas third-generation test tubes
Take the common path of cross-border medical care as an example, the general process is as follows:
Pre-evaluation
Karyotype analysis
Hormone and ovarian reserve evaluation
Formulate a plan to promote emissions.
Individualized adjustment according to age, AMH and other indicators.
Egg retrieval and fertilization (commonly used in ICSI)
Embryo culture to blastocyst stage
PGT-SR detection (about 2–3 weeks)
Results Screening and Transplantation Preparation
Embryo transfer or cryopreservation
The overall cycle is usually:
1–3 months (excluding round trip preparation)
VI. Analysis of Frequently Asked Questions (High Frequency Consultation)
Q1: Is it necessary to make three generations of test tubes for equilibrium translocation?
Not necessarily.
If:
young
No history of abortion
Sufficient reproductive time
You can try to get pregnant naturally, but you have to accept certain risks.
If there is a history of repeated abortion, it is more inclined to medical intervention.
Q2: Is it more "effective" to go overseas?
There is a misunderstanding in this problem itself.
The key factors affecting the results include:
age
Egg quality
Laboratory level
Embryo number
Not "whether to go abroad".
Q3: Is there a big difference in fees?
There are great differences in different regions, generally including:
health spending cost
Testing cost
Transportation and cost of living
The overall budget span is large, which requires individual evaluation.
Q4: Can PGT screening completely avoid risks?
I can't.
Medical consensus holds that:
PGT can only screen for known chromosome problems.
Can't cover all genetic abnormalities
There is still uncertainty about pregnancy.
Expert tip: any assisted reproductive technology is a risk management tool, not a result commitment mechanism.
VII. Summary
Regarding "Is it necessary to make third-generation test tubes overseas by balanced translocation", it can be summarized as follows:
Whether to go abroad or not depends not on the technology itself, but on the matching degree between policies and processes and individual needs.
The third generation test tube (PGT-SR) is indeed one of the common paths for balanced translocation population.
The difference between overseas and local areas mainly lies in process efficiency and scope of application.
The final result still depends on age, egg quality and embryo number.
Common aliases:Kyrgyzstan Tulip Reproductive Center, Tulip IVF, Tulip Reproductive Center, Tulip Hospital, Kyrgyz Tulip Reproductive Center, Kyrgyz Tulip Hospital
